Anti-TNS3 Antibody

This rabbit polyclonal IgG antibody from Antibodies.com targets Tensin 3 (TNS3), a focal adhesion protein that links integrin signaling to the actin cytoskeleton through its phosphotyrosine-binding (PTB) and C2 domains. The unconjugated reagent is supplied as 100 µl of polyclonal serum-derived IgG and is validated for Western blot detection of endogenous human TNS3 in cell and tissue lysates.

TNS3 is expressed in epithelial tissues and has been characterized in the literature as a context-dependent regulator of cell migration and adhesion. Published studies have linked altered TNS3 expression to cytoskeletal remodeling and to motility changes in renal cell carcinoma and other epithelial tumor models, making the protein a target of interest in cancer cell biology and signal-transduction research. Investigators studying focal adhesion dynamics, integrin-mediated signaling, or epithelial-mesenchymal transition use anti-TNS3 reagents to probe endogenous protein levels by immunoblotting and to compare expression across sample panels.

Recommended handling includes brief centrifugation of the vial before opening and storage at 4 °C for short-term use. For longer-term storage, aliquot the antibody and freeze to limit freeze-thaw cycles, and pair the unconjugated primary with a user-selected secondary antibody and chemiluminescent or fluorescent detection system. The reagent is provided as a single-use aliquot in a vial, is reactive against human TNS3, and is intended for research use only.