Anti-TNR16 Antibody

A rabbit polyclonal antibody from Antibodies.com targets TNR16, the low-affinity nerve growth factor receptor also designated p75NTR or NGFR. This TNFRSF16 member binds NGF, BDNF, NT-3, and NT-4/5 with comparable affinity and mediates opposing cellular outcomes, including neuronal survival, programmed cell death, and Schwann cell migration during nerve development. The unconjugated reagent is supplied in a 100 µl vial and has been validated for Western blot (WB) and immunofluorescence (IF) on Human, Mouse, and Rat specimens, supporting translational neuroscience, dorsal root ganglia profiling, and peripheral nerve injury studies. Investigators working on neurotrophin signaling, neural crest development, or oligodendrocyte precursor biology can apply the antibody to transferred membrane protein and detect a band near 75 kDa, or use it on fixed cryosections to localize receptor distribution in hippocampus, sympathetic neurons, and basal forebrain cholinergic populations. The unconjugated format allows flexible pairing with user-preferred reporter chemistries, including Alexa Fluor dyes, horseradish peroxidase, or biotin, depending on the imaging or detection platform. Keep the vial refrigerated between uses, aliquot upon first thaw, and limit repeated freeze-thaw cycles to preserve binding activity across long-term studies of neurodevelopment and neurodegeneration.