Anti-TNP2 Antibody

Raised in rabbit against the human transition nuclear protein 2 (TNP2), this unconjugated polyclonal antibody from Antibodies.com targets a spermatid-specific nuclear protein involved in histone-to-protamine chromatin remodeling during late spermiogenesis. TNP2 studies are central to male germ cell differentiation and idiopathic infertility research, where altered expression or post-translational modification of transition proteins is linked to defective sperm chromatin condensation.

Supplied as 100 µl of a 1 mg/ml stock in PBS containing 0.1% sodium azide and 50% glycerol as a cryoprotectant, the reagent is validated for western blot, immunohistochemistry, and immunofluorescence workflows on human samples. The polyclonal format provides recognition of multiple epitopes across the TNP2 primary sequence, useful when probing cleavage fragments or modified forms. Aliquot upon arrival and store frozen at -20 °C to preserve activity across freeze-thaw cycles; the glycerol and azide formulation allows short-term bench use without contamination concerns.

Recommended for academic and clinical research laboratories investigating testicular biopsy material, ejaculated sperm chromatin fractions, or transfected cell models of haploid germ cell development. Researchers should perform their own optimization of dilution and antigen retrieval for IHC and IF, since fixation and embedding conditions affect TNP2 epitope accessibility.