Anti-TNFSF13 Antibody

This rabbit polyclonal antibody recognizes human, mouse, and rat TNFSF13, the TNF superfamily cytokine commonly referred to as APRIL. Produced by Antibodies.com as an unconjugated primary reagent, the antibody is supplied as 100 µL of affinity-purified Ig suitable for western blot (WB) and immunofluorescence (IF) workflows.

TNFSF13/APRIL is a type II transmembrane ligand that drives B-cell maturation, class-switch recombination, and T-cell-independent humoral responses through engagement of the TACI and BCMA receptors. Researchers studying multiple myeloma, chronic lymphocytic leukemia, systemic lupus erythematosus, and other autoimmune or lymphoproliferative conditions rely on validated TNFSF13 detection tools to map signaling contributions, receptor binding, and circulating ligand levels in cell culture models and tissue samples.

The polyclonal format offers multi-epitope coverage against the TNFSF13 protein backbone, supporting detection of full-length and soluble APRIL cleavage products in cell lysates and fixed-cell preparations. Recommended starting dilutions and buffer conditions should be optimized empirically per application; aliquot upon first thaw to limit freeze-thaw cycles and protect from light when the unconjugated primary is paired with a fluorescent secondary for IF imaging.