Anti-TNFRSF4 Antibody

This polyclonal primary antibody targets TNFRSF4 (also known as OX40 or CD134), a member of the tumor necrosis factor receptor superfamily that functions as a T-cell costimulatory receptor. Produced in rabbit and supplied at 1 mg/ml in phosphate buffered saline with 0.05% sodium azide at approximately pH 7.3, this unconjugated reagent is validated for Western Blot (WB) workflows across Human, Mouse, and Rat samples.

TNFRSF4 is expressed primarily on activated CD4+ and CD8+ T cells, where engagement by its ligand (OX40L) drives proliferation, survival signaling, and cytokine production. Researchers studying immune checkpoint biology, autoimmune disease models, transplant rejection, and cancer immunotherapy use this reagent to track receptor expression and modulation in lymphoid tissues and tumor-infiltrating lymphocytes.

The antibody is supplied as a 100 µl liquid aliquot, ready for dilution into standard WB blocking and incubation buffers. Because the formulation contains sodium azide as a preservative, it is intended for research use only. For short-term use, refrigerated storage preserves reagent activity; for longer-term storage, aliquot and freeze to maintain stability and minimize freeze-thaw cycles.

Provided by Antibodies.com, this polyclonal reagent supports detection of endogenous TNFRSF4 in cell lysates and tissue homogenates by immunoblotting. The unconjugated format allows pairing with secondary antibodies of the researcher's choice (HRP, fluorescent, or biotin conjugates), supporting flexible detection strategies in immunology and cell signaling research.