Anti-TNFRSF21 Antibody

This polyclonal reagent from Antibodies.com is an unconjugated IgG preparation raised in rabbit against TNFRSF21, a death-domain-containing member of the TNF receptor superfamily also designated DR6. The antibody is supplied as 50 µl of ready-to-use or titratable liquid for western blot workflows and was validated to detect the human protein. Because the product is unconjugated, individual laboratories can attach a preferred reporter enzyme, biotin, or fluorophore of their choice for downstream visualization on immunoblots. Polyclonal preparations of this kind typically engage multiple epitopes across the extracellular and intracellular regions of TNFRSF21, which is helpful when probing for full-length receptor expression in cell-line lysates. Research groups investigating apoptosis signaling, T-cell costimulation, and amyloid-β–related neuronal death pathways routinely use anti-TNFRSF21 antibodies to follow DR6-dependent caspase activation and downstream JNK signaling. For best results, store the vial at –20 °C in single-use aliquots to limit freeze-thaw cycles and protect the IgG from activity loss; avoid prolonged exposure to room temperature and protect from light if a conjugated secondary will be added later. The product is intended for research use only and is not validated for diagnostic or therapeutic applications.