Anti-TNFRSF21 Antibody

This unconjugated Rabbit polyclonal IgG antibody from Antibodies.com is raised against Tumor Necrosis Factor Receptor Superfamily member 21, a death-domain-containing cell-surface receptor widely studied in apoptosis signaling, T-cell costimulation, and inflammatory pathway research. Produced in rabbit and validated for Western blot detection of the human target, the reagent is supplied as 200 µL of polyclonal antiserum in a single-use vial, with no fluorophore or enzyme label attached so it can be paired with the secondary reagent of choice. The antibody recognizes TNFRSF21, also designated DR6 or CD358, a type I transmembrane protein that recruits TRADD and activates NF-κB and JNK signaling, and that has been linked to Th17 differentiation, oligodendrocyte maturation, and amyloid precursor protein processing in the published literature. Researchers studying autoimmune disease models, neuroinflammation, or DR6-mediated death signaling can use this reagent to probe endogenous TNFRSF21 expression in human cell lysates and tissue homogenates.