Anti-TNFRSF17 Antibody

This unconjugated polyclonal reagent from Antibodies.com targets TNFRSF17 (BCMA), the B-cell maturation antigen selectively expressed on mature B cells, plasmablasts, and long-lived bone marrow plasma cells. Raised in rabbit, the antibody is supplied as a 100 µl volume of antiserum ready for incorporation into standard immunodetection workflows. Cross-reactivity with both human and mouse TNFRSF17 enables comparative work between clinical specimens and rodent disease models.

Validated applications include western blot analysis of B-cell lysates, where the reagent recognizes the mature receptor at its expected molecular weight, and immunohistochemistry on lymphoid and bone marrow tissue sections for cellular localization studies. Investigators use this antibody to characterize germinal center B-cell populations, trace plasma cell differentiation programs, and probe NF-κB-driven survival signaling in multiple myeloma cell lines and primary biopsies.

Each vial is intended for research use only, supporting in vitro investigations of BAFF and APRIL ligand-driven signaling, autoantibody-secreting cell biology in autoimmune disease, and therapeutic target validation in oncology. For best preservation of binding activity, store aliquots frozen at -20°C and keep a working stock refrigerated at 4°C to limit repeated freeze-thaw cycles.