Anti-TNFRSF13B Antibody

Raised in rabbit against TNFRSF13B, this polyclonal IgG reagent from Antibodies.com is supplied as an unconjugated preparation intended for western blot and immunohistochemistry workflows. TNFRSF13B, also known as TACI (transmembrane activator and calcium modulator and cyclophilin ligand interactor), is a member of the TNF receptor superfamily that binds the BAFF and APRIL cytokines and mediates signaling central to B-cell maturation, class-switch recombination, and antibody production. Studies have linked loss-of-function variants in TNFRSF13B to common variable immunodeficiency (CVID), IgA deficiency, and lymphoproliferative phenotypes, making the receptor a frequent subject of immunology and hematology research.

The antibody cross-reacts with human and mouse TNFRSF13B and is provided at 50 µl per vial, sufficient for multiple blotting or staining experiments. As an IgG isotype in an unconjugated format, it accommodates custom detection chemistries, including HRP-, biotin-, or fluorophore-conjugated secondary antibodies, allowing adaptation to varied imaging and detection platforms. Common research applications include western blot analysis of lymphoid tissue lysates, immunohistochemistry on tonsil or spleen sections for germinal-center B-cell staining, and basic research investigations into B-cell receptor signaling pathways.

Storage and handling should follow standard primary antibody practices: aliquot upon first use to limit freeze-thaw cycles and store refrigerated for short-term use or frozen for longer-term stability. The reagent is intended for research use only and is not validated for diagnostic or therapeutic applications.