Anti-TNFRSF11B Antibody

Manufactured by Antibodies.com as a primary antibody reagent for osteoimmunology and bone biology research, this affinity-purified reagent targets TNFRSF11B (also known as OCIF, OPG, osteoclastogenesis inhibitory factor, or tumor necrosis factor receptor superfamily member 11B). It is a rabbit polyclonal antibody raised against a recombinant human TNFRSF11B immunogen and validated for Western blot (WB) and immunohistochemistry (IHC) applications, with reactivity confirmed in human, mouse, and rat samples. The unconjugated antibody is supplied at a concentration of 1.0 mg/mL in a 50 µL volume, formulated in phosphate-buffered saline without Mg²⁺ and Ca²⁺ at pH 7.4, containing 150 mM NaCl, 0.02% sodium azide as preservative, and 50% glycerol for cryoprotection. The polyclonal host (rabbit) and unconjugated format make it suitable for custom labelling or for use with secondary detection systems of the researcher's choice. Each lot detects the endogenous total TNFRSF11B protein, enabling studies of osteoprotegerin expression in bone remodelling, vascular biology, and tumour microenvironments. Shipping is performed cold-packed at 4 °C, and on arrival the antibody should be stored at –20 °C, with repeated freeze/thaw cycles avoided to preserve activity. Provided for research use only, the reagent offers a reliable tool for laboratories investigating decoy receptor signalling pathways in inflammation, bone density regulation, and related translational research.