Anti-TNFRSF11B Antibody

Raised in rabbit and validated for Western blot (WB) and immunohistochemistry (IHC), this unconjugated polyclonal antibody from Antibodies.com targets TNFRSF11B, a TNF receptor superfamily member also known as Osteoprotegerin (OPG). OPG functions as a soluble decoy receptor for RANKL and TRAIL, inhibiting osteoclast differentiation and modulating bone resorption, vascular calcification, and immune signaling. Cross-reactivity covers human, mouse, and rat samples, supporting translational studies in bone metabolism, cardiovascular biology, and inflammation research.

Each vial contains 100 µl of polyclonal antiserum in an unconjugated format, which permits pairing with HRP-, biotin-, or fluorophore-labeled secondary reagents for chemiluminescent or fluorescence readouts. The reagent is suited to detecting endogenous OPG in cell or tissue lysates via WB and to localizing the receptor in fixed sections via IHC. For handling, aliquot upon arrival and store at -20 °C for long-term use, limiting freeze-thaw cycles to preserve antibody performance across multiple experiments.