Anti-TNFRSF10B Antibody

This rabbit polyclonal primary antibody from Antibodies.com targets TNFRSF10B, a death-domain containing cell surface receptor also referred to as TRAIL-R2, DR5, KILLER, or CD262. TNFRSF10B binds the cytokine TRAIL and recruits the adaptor protein FADD to assemble the death-inducing signaling complex (DISC), activating caspase-8 and triggering the extrinsic apoptosis cascade that eliminates damaged or cancerous cells.

The reagent is supplied as 100 µL of unconjugated antiserum raised in rabbit and is validated for Western blot (WB) and immunohistochemistry (IHC) applications on human specimens. As a polyclonal reagent, it recognizes multiple epitopes across TNFRSF10B, which can improve signal detection in tissues where receptor expression is low, patchy, or modified post-translationally.

TNFRSF10B is widely studied in oncology research because TRAIL receptor signaling offers a route to selectively induce apoptosis in malignant cells while sparing most normal tissue. Investigators use this Antibodies.com reagent to assess death receptor expression in tumor biopsies, profile sensitivity or resistance to TRAIL-based therapeutics, and monitor DISC assembly in cultured cell line models. Researchers evaluating combination regimens that resensitize resistant tumors to TRAIL-mediated killing also rely on TNFRSF10B detection by WB and IHC as a quantitative readout of receptor status.