Anti-TNFRSF10B Antibody

Raised in rabbit against the human TNFRSF10B receptor (also known as DR5, TRAIL-R2, or TRICK2), this unconjugated polyclonal antibody from Antibodies.com is supplied as 100 µl of a 1 mg/ml stock in PBS with 0.1% Sodium Azide and 50% glycerol, ready to dilute into standard assay buffers. TNFRSF10B is a death-domain-containing member of the TNF receptor superfamily that binds TRAIL and transduces apoptotic signaling, and it is widely investigated as a tumor-selective therapeutic target in cancer cell lines and tumor tissue sections.

The reagent has been validated for western blot and immunohistochemistry on human samples, supporting detection of the receptor in cell lysates as well as formalin-fixed paraffin-embedded tissue. Researchers studying TRAIL pathway sensitivity, resistance mechanisms in carcinoma and melanoma models, or receptor upregulation following chemotherapeutic stress commonly pair this antibody with appropriate isotype controls.

Storage: the glycerol-containing formulation is stable at -20°C for long-term storage and tolerates repeated freeze-thaw cycles; working aliquots for routine western blot work may be refrigerated short-term at 4°C. Brief centrifugation before opening is recommended to recover the full volume.