Anti-TNFRSF10B Antibody

Raised in rabbit and supplied by Antibodies.com, this affinity-purified polyclonal reagent is designed for the selective detection of TNFRSF10B (also known as DR5, TRAIL-R2 or CD262), a death-domain-containing member of the TNF receptor superfamily that mediates TRAIL-induced apoptosis. The antibody is provided as a 50 µL liquid stock at 1 mg/mL in PBS containing 0.1% sodium azide and 50% glycerol as a cryoprotectant, and it is unconjugated, allowing it to be paired freely with the secondary reporter of the user's choice in standard immunodetection workflows. Validated reactivity covers human, mouse and rat samples, making the reagent suitable for comparative studies across these commonly used model systems. The recommended application is Western Blot, where the antibody is expected to recognise the relevant receptor band in lysates derived from TNFRSF10B-expressing cells and tissues. Because the product is classified for Research Use Only, end users should reserve it for in vitro research and avoid diagnostic or therapeutic applications. For best stability, the vial should be stored at -20 °C in small aliquots, avoiding repeated freeze-thaw cycles; under these conditions the glycerol-containing buffer preserves antibody activity over extended periods. Polyclonal preparations such as this one offer broader epitope coverage than monoclonal reagents, which is particularly useful when studying a receptor such as DR5 whose different isoforms and post-translational states can vary between cell types and experimental conditions. As supplied by Antibodies.com, the reagent is intended to give consistent performance across replicate blots, supporting reproducible detection of TNFRSF10B in apoptosis, p53 signalling and cancer-research workflows.