Anti-TNFAIP8L1 Antibody

This rabbit polyclonal antibody targets TNFAIP8L1, also referred to as TIPE1, a member of the TNF-alpha-induced protein 8 family that modulates programmed cell death, autophagy, and inflammatory signaling through the NF-κB pathway. From Antibodies.com, the unconjugated primary antibody is provided as 100 µl of liquid at 1 mg/ml in phosphate buffered saline with 15 mM sodium azide at approximately pH 7.2. The reagent is validated for Western blot detection of the human, mouse, and rat target, making it useful for cross-species expression studies in cell lysate and tissue homogenate preparations.

TNFAIP8L1 has attracted research interest as a regulator of apoptosis and innate immunity, with altered expression reported in hepatocellular carcinoma, gastric cancer, and lung adenocarcinoma. Investigators studying TNF receptor signaling, inflammasome biology, and chemotherapeutic response use anti-TIPE1 reagents to monitor endogenous levels, confirm RNAi or CRISPR knockdown efficiency, and probe how expression shifts in response to inflammatory cytokines. The polyclonal format yields broad epitope coverage on denatured lysates typical of Western blot workflows. Store refrigerated in the dark, protect from light, aliquot to limit freeze-thaw cycles, and centrifuge vials briefly before opening to recover full volume.