Anti-TNFAIP6 Antibody

Raised in rabbit and supplied as a 100 µl aliquot at 1 mg/ml, this unconjugated polyclonal primary antibody recognizes TNFAIP6 (also known as TSG-6, or tumor necrosis factor alpha induced protein 6) in human and rat samples for Western blot workflows. The reagent is formulated in phosphate buffered saline (PBS) containing 0.05% sodium azide as a preservative, adjusted to approximately pH 7.3 for direct dilution into standard reducing sample buffers and blot processing steps.

TNFAIP6 is a hyaluronan-binding, TNF-α-inducible secreted factor that has been investigated in the context of extracellular matrix assembly, inflammatory signaling, and tissue remodeling. Antibodies.com provides this reagent for researchers studying TSG-6 expression in osteoarthritis and rheumatoid arthritis models, in cumulus-oocyte complex expansion during ovulation, and in mesenchymal stem cell-mediated modulation of acute inflammatory injury, where the protein influences protease activity, hyaluronan organization, and leukocyte trafficking at the cell surface.

The unconjugated format permits flexible pairing with HRP-conjugated, biotinylated, or fluorophore-labeled secondary reagents to suit different Western blot detection platforms. Because TNFAIP6 is both secreted and deposited in pericellular matrices, this polyclonal reagent supports detection of the full-length protein in cell lysates, conditioned medium, and tissue homogenates, and is well suited to recognizing epitope variants generated by proteolytic processing during inflammation. The 0.05% sodium azide present in the storage buffer helps maintain antibody activity during refrigerated handling; aliquoting is recommended to limit repeated freeze-thaw cycles when the reagent is used across multiple experiments.