Anti-TNFAIP3 Antibody

Rabbit polyclonal antibody raised against TNFAIP3, also called A20, a TNF-α-induced zinc finger protein with dual ubiquitin-editing activity (E3 ligase plus deubiquitinase) that terminates NF-κB signaling downstream of receptors such as TNFR1, TLR4, and NOD2. Antibodies.com supplies this reagent at 100 µl per vial, unconjugated and affinity-purified, validated for Western blot, immunohistochemistry on formalin-fixed sections, and immunofluorescence imaging.

The reagent detects endogenous TNFAIP3 in human, mouse, and rat samples, supporting research into inflammation resolution, autoimmune disease models, and B-cell lymphomas where loss-of-function mutations in A20 have been repeatedly documented. The unconjugated format allows flexible pairing with HRP-, biotin-, or fluorophore-conjugated secondary antibodies. For storage, keep the vial at -20°C, avoid repeated freeze-thaw cycles by aliquoting on first use, and titrate empirically across each application to optimize signal-to-noise.