Anti-TNF-R1 Antibody

This unconjugated polyclonal antibody from Antibodies.com is raised in rabbit and binds TNF-R1 (tumor necrosis factor receptor 1), the 55 kDa transmembrane receptor that mediates classical TNF-alpha signaling through NF-κB activation and caspase-dependent apoptosis. Supplied as 100 µl of reagent, it is validated for western blot, immunohistochemistry, and immunofluorescence workflows and shows reactivity with human, mouse, and rat samples, supporting comparative studies across rodent models and human tissues.

TNF-R1 is widely investigated in inflammation, sepsis, neurodegeneration, and tumor biology, where altered receptor expression is tied to disease progression and drug response. The polyclonal format increases the likelihood of recognizing multiple epitopes on the receptor, which can be useful when working with denatured lysates for western blot or with fixed tissue sections for IHC, and the unconjugated preparation lets researchers pair the antibody with their preferred secondary reagent and detection system.