Anti-TNF alpha Antibody [CH8820]

Tumor Necrosis Factor alpha (TNF-alpha) is a potent pro-inflammatory cytokine central to innate immune signaling, with documented roles in chronic inflammatory pathology such as rheumatoid arthritis, inflammatory bowel disease, and psoriasis. This unconjugated Mouse IgG1 monoclonal antibody, clone CH8820, binds human TNF-alpha and is supplied by Antibodies.com as a lyophilised preparation of 100 µg, reconstituted in sterile buffer prior to use.

Validation covers ELISA and immunohistochemistry (IHC), supporting work that ranges from quantifying cytokine release in cell culture supernatants to localising TNF-alpha-producing cells in fixed tissue sections. Because the antibody is unconjugated, laboratories can pair it with HRP, biotin, or fluorophore-conjugated secondary reagents of their choice, adapting it to chromogenic, fluorescence, or tyramide-based detection workflows as needed.

Reactivity is confirmed against human TNF-alpha; cross-reactivity with other species has not been established. The lyophilised powder should be stored refrigerated after reconstitution, with aliquoting into single-use vials recommended to limit repeated freeze-thaw cycles. For research use only; not intended for diagnostic or therapeutic applications.