Anti-TMPRSS2 Antibody

This rabbit polyclonal reagent from Antibodies.com targets the transmembrane serine protease TMPRSS2, a type II protein first characterized in prostate epithelium and later recognized for its central role in SARS-CoV-2 entry into host cells. Supplied as 100 µl of a 1 mg/ml stock in PBS with 0.1% sodium azide and 50% glycerol, the unconjugated antibody is validated for western blot (WB) and immunohistochemistry (IHC) workflows and cross-reacts with human, mouse, and rat samples. Researchers apply it to probe androgen-responsive regulation of TMPRSS2 in prostate tissue, to assess expression in airway and intestinal epithelia, and to investigate the protease's contribution to viral spike protein priming in infection models. The polyclonal format offers recognition across multiple epitopes of the target, which is useful when probing expression changes or cleavage events that may shift the dominant antigenic region. Aliquoting upon arrival is recommended to minimize repeated freeze-thaw cycles of the glycerol-containing stock.