Anti-TMPRSS11F Antibody

Produced as a rabbit polyclonal reagent by Antibodies.com, this unconjugated primary antibody targets TMPRSS11F, a type II transmembrane serine protease (TTSP-family member, also referenced as HATL2) that localizes to epithelial barriers and is implicated in keratinization and proteolytic cascade regulation.

Validated for Western blot (WB) and immunohistochemistry (IHC), the reagent shows reactivity against both human and mouse samples, supporting translational and preclinical workflows that compare orthologous expression across species. The unconjugated format allows researchers to pair it with their preferred reporter labels, fluorophores, or chromogens for either chromogenic or fluorescence-based detection.

Each vial is supplied as a 100 µl liquid aliquot of the polyclonal host serum fraction. Standard short-term storage at 4 °C in the supplied buffer is recommended, with aliquoting and freezing at -20 °C advised for longer-term stability to preserve activity across multiple thaw cycles. A centrifugation step before opening is recommended to recover the full volume.

TMPRSS11F is expressed in differentiated squamous epithelium of the upper aerodigestive tract, in skin, and in prostate tissue, and is being investigated alongside related type II serine proteases for its role in epithelial homeostasis, cornified envelope formation, and as a candidate in viral entry studies. Scientists working on barrier biology, prostate tissue proteases, head-and-neck squamous tissue characterization, or comparative rodent and human epithelial models will find this reagent useful for protein detection, expression profiling, and tissue localization studies.