Anti-TMEM57 Antibody

The Anti-TMEM57 Antibody from Antibodies.com is a rabbit polyclonal IgG reagent supplied as a 100 µg liquid aliquot, raised against the human transmembrane protein 57 (TMEM57) target, also referenced in the literature as MACO1 or C9orf127. The antibody is unconjugated and validated for Western blot (WB) detection of endogenous TMEM57 in both human and mouse samples, making it a practical tool for studies in cell biology, neuroscience, and developmental biology research.

TMEM57 encodes a multi-pass transmembrane protein localized to endoplasmic reticulum and Golgi membranes, with reported roles in intracellular trafficking, planar cell polarity signaling, and neural tube closure during embryogenesis. Researchers commonly use this reagent to examine TMEM57 expression in whole-cell lysates, to investigate its involvement in Wnt and ciliopathy-related pathways, or to map tissue distribution across mouse and human model systems. Each vial contains the stated 100 µg of IgG in a buffered liquid formulation; users should follow the manufacturer's storage guidance (-20 °C for long-term storage, with aliquoting to limit freeze-thaw cycles) and standard Western blot workflows using PVDF or nitrocellulose transfer, blocking in 5% non-fat milk or BSA, and chemiluminescent or fluorescent detection.