Anti-TLR7 Antibody

The TLR7 (Toll-like receptor 7) protein is an endosomal pattern recognition receptor central to innate antiviral immunity, where it detects single-stranded RNA from viruses and drives type I interferon production. This Antibodies.com polyclonal reagent is raised in rabbit against TLR7 and supplied unconjugated in a 100 µL vial, ready for direct labeling or standard detection workflows.

Validated applications include Western blot for protein expression profiling and immunofluorescence for subcellular mapping of TLR7 in endosomal compartments. Demonstrated reactivity spans human, mouse, and rat samples, supporting comparative immunology research across common mammalian model systems.

Typical research contexts include viral sensing studies, autoimmune disease models such as systemic lupus erythematosus where TLR7 hyperactivation contributes to pathology, adjuvant response research involving imidazoquinoline compounds, and characterization of plasmacytoid dendritic cell function. The unconjugated format provides flexibility for HRP, fluorophore, or biotin conjugation depending on experimental design. Storage at refrigerated temperatures with aliquoting to limit repeated freeze-thaw cycles is recommended to preserve antibody activity over long-term use.