Anti-TLE1 Antibody

TLE1 (Transducin-Like Enhancer of Split 1) is a transcriptional co-repressor of the Drosophila Groucho/TLE family, and the unconjugated rabbit polyclonal reagent from Antibodies.com provides a versatile primary antibody for tracking its expression across human, mouse, and rat model systems.

Supplied as 100 µl of liquid antiserum, this Antibodies.com product is validated for western blot, immunohistochemistry, and immunofluorescence workflows and recognizes an epitope within the conserved C-terminal WD40-repeat domain shared among vertebrate TLE orthologs.

In diagnostic pathology, TLE1 immunostaining is widely used as an ancillary marker for synovial sarcoma, helping distinguish this translocation-driven malignancy from histologic mimics such as malignant peripheral nerve sheath tumor and fibrosarcomatous dermatofibrosarcoma, while in developmental biology the same reagent supports studies of Notch- and Wnt-mediated transcriptional repression, hematopoietic stem cell maintenance, and neuronal differentiation.

For long-term storage, keep the vial at -20 °C in working aliquots to minimize freeze-thaw degradation of the polyclonal stock, and pair the antibody with appropriate HRP- or fluorophore-conjugated secondary reagents depending on the chosen detection platform.