Anti-TIRAP Antibody

The TIRAP (TIR domain-containing adaptor protein), also known as MAL, serves as a critical bridging adaptor that connects Toll-like receptor 2 and Toll-like receptor 4 to the downstream MyD88-dependent signaling cascade that drives innate immune activation. This unconjugated polyclonal reagent, raised in rabbit, detects endogenous TIRAP in Human, Mouse, and Rat samples and is validated for Western blot and immunohistochemistry workflows. It is supplied at 1 mg/ml in PBS with 0.1% Sodium Azide and 50% Glycerol as a 100 µl volume, ready to dilute into standard blocking buffers for immunoblotting or to apply directly to fixed tissue sections. Researchers studying TLR signal transduction, inflammatory cytokine output, and adaptor protein recruitment in macrophages, dendritic cells, and epithelial models will find the polyclonal format advantageous when mapping TIRAP expression across multiple epitopes. For best results, store frozen at -20 degrees C in single-use aliquots to limit freeze-thaw cycles and preserve antibody activity over the working shelf life. Sourced from Antibodies.com, this Primary Antibody supports programs in sepsis research, autoimmune disease modeling, and infectious disease susceptibility studies where TIRAP-mediated pathway activity is a variable of interest.