Anti-TIMP3 Antibody

TIMP3 (Tissue Inhibitor of Metalloproteinases 3) is a 24 kDa protein anchored in the extracellular matrix, where it inhibits matrix metalloproteinases (MMPs) and several ADAM and ADAMTS family members to regulate tissue remodeling, inflammation, and angiogenesis. This rabbit polyclonal antibody from Antibodies.com was raised against TIMP3 and is validated for Western blot (WB) and immunofluorescence (IF) workflows on human, mouse, and rat samples.

Because it is supplied unconjugated, the reagent can be paired with a secondary antibody of choice, and the polyclonal format supports recognition of multiple epitopes on the endogenous target. Each vial contains 100 µl of liquid, enough for several Western blot membranes or IF staining experiments depending on dilution. Research applications include studies of extracellular matrix turnover, retinal disease models (mutations in TIMP3 cause Sorsby's fundus dystrophy), and tumor microenvironments, where TIMP3 frequently acts as a tumor suppressor.

For handling, store the vial at -20 °C in small aliquots to limit freeze-thaw cycles and preserve antibody activity across multiple experiments. Intended for research use only.