Anti-TIMP-4 Antibody

The Antibodies.com rabbit polyclonal reagent targets TIMP-4, a 22 kDa tissue inhibitor of metalloproteinases that regulates extracellular matrix remodeling by suppressing MMP-2 and MMP-9 activity. Supplied as 100 µl of unconjugated antiserum, this primary antibody supports Western blot, immunohistochemistry, and ELISA workflows across human, mouse, and rat samples.

Researchers studying cardiac fibrosis, tumor invasion, or vascular pathology use TIMP-4 detection to probe disease-linked shifts in matrix turnover. The polyclonal format increases epitope coverage for robust signal in tissue lysates and fixed sections, while the unconjugated state allows flexible pairing with custom reporter labels. Recommended storage at -20 °C in working aliquots preserves activity through multiple freeze-thaw cycles, and the cross-species reactivity profile supports translational comparisons between rodent disease models and human clinical specimens.