Anti-TIMP-1 Antibody

Raised in rabbit against Tissue Inhibitor of Metalloproteinases 1 (TIMP-1), this polyclonal primary antibody from Antibodies.com targets a glycoprotein that regulates matrix metalloproteinase (MMP) activity and extracellular matrix turnover. Supplied as 100 µl of unconjugated antisera, the reagent is validated for Western Blot (WB) and ELISA workflows and shows reactivity with Human, Mouse, and Rat samples, supporting translational research across species.

TIMP-1 balances protease activity in connective tissue, epithelial barriers, and immune signaling pathways, so it is routinely investigated in studies of fibrosis, tumor invasion, wound healing, and inflammatory disease. Researchers use this reagent to probe secreted and intracellular pools of TIMP-1, to monitor MMP/TIMP balance under experimental perturbation, and to characterize expression changes in cell culture models and animal tissue lysates. The polyclonal format recognizes multiple epitopes on the TIMP-1 molecule, which can improve signal recovery when target abundance is low or when the protein is partially degraded.

As an unconjugated antibody, it offers flexibility for downstream labeling: laboratories can pair it with HRP, biotin, fluorophore, or alkaline phosphatase conjugates of their choice to tailor detection chemistry for chromogenic western blotting or ELISA plate assays. Store refrigerated and aliquot upon arrival; protect from light and limit freeze-thaw cycles to preserve binding activity.