Anti-Thyroid Hormone Receptor α Antibody

Produced in rabbit as a polyclonal antiserum, this unconjugated primary antibody from Antibodies.com recognizes Thyroid Hormone Receptor α (TRα), a nuclear receptor that mediates thyroid hormone (T3) signaling. The immunogen-derived reagent binds multiple epitopes on the receptor protein, supporting consistent detection of the native target in tissue and cell lysates. The reagent is supplied as a 50 µl aliquot of unconjugated rabbit Ig, validated for western blot (WB) and immunohistochemistry (IHC) workflows in human, mouse, and rat specimens.

Thyroid hormone receptors govern transcription of genes controlling basal metabolic rate, cardiac output, intestinal maturation, and central nervous system myelination. Research-grade antibodies against TRα are commonly used to study hypothyroidism, cardiac hypertrophy, gut development, and disorders of nuclear hormone signaling, including resistance to thyroid hormone (RTH). Because the target is a nuclear transcription factor, IHC staining typically highlights nuclear localization in hepatocytes, cardiomyocytes, enterocytes, and select neuronal populations.

Recommended handling: aliquot the antibody upon first thaw to limit freeze-thaw cycles, refrigerate for short-term use, or store frozen for longer projects. The polyclonal format provides broader epitope coverage than a monoclonal reagent, which can be useful when probing whole-tissue lysates by WB or mapping receptor distribution across a developmental time course by IHC.