Anti-Thiopurine S-methyltransferase Antibody

Thiopurine S-methyltransferase (TPMT) catalyzes S-adenosyl-L-methionine-dependent methylation of thiopurine drugs such as azathioprine and 6-mercaptopurine, and inherited TPMT deficiency is a well-established pharmacogenetic risk factor for life-threatening myelosuppression during standard thiopurine therapy.

This unconjugated rabbit polyclonal reagent from Antibodies.com is raised against human TPMT and supports detection of the endogenous enzyme by Western blot and immunohistochemistry on human-derived samples. Supplied as a 100 µg aliquot in a single vial, the antibody enables laboratories studying pharmacogenomics, drug metabolism, or hematotoxicity pathways to characterize TPMT expression in patient tissue or cell lysates.

The polyclonal format increases the likelihood of recognizing multiple epitopes across the TPMT protein, which is useful when probing for isoform variants, patient-derived polymorphisms, or partial degradation products relevant to clinical TPMT activity studies.