Anti-TH (phospho S40) Antibody

Phospho-Specific Antibody for Tyrosine Hydroxylase Research

This rabbit polyclonal antibody from Antibodies.com selectively recognizes tyrosine hydroxylase (TH) phosphorylated at serine 40, a regulatory site whose modification by PKA, CaMKII, and other kinases is associated with enzyme activation and accelerated catecholamine biosynthesis. The unconjugated IgG reagent is supplied as 200 µl of polyclonal antiserum validated for immunofluorescence on human, mouse, and rat samples, making it well matched to studies of dopaminergic, noradrenergic, and adrenergic neuron function in both cultured cells and fixed tissue sections.

Researchers use this reagent to probe signaling-dependent changes in catecholaminergic pathways, including models of stress response, neurodegeneration, and pharmacological modulation where phospho-S40 levels report kinase activity in situ. Because the antibody is unconjugated, it pairs flexibly with a wide choice of labeled secondary reagents and supports multiplex immunofluorescence panels. Store at 2 to 8 degrees C and protect from light to preserve reagent performance across repeated staining runs.