Anti-TH (phospho S19) Antibody - Identical to Abcam (ab194785)

This unconjugated rabbit polyclonal antibody from Antibodies.com targets tyrosine hydroxylase (TH) when phosphorylated at serine 19, a CaMKII-associated regulatory modification of the rate-limiting enzyme in catecholamine biosynthesis. Provided as 200 µl of IgG, the reagent is supplied as a polyclonal preparation equivalent to the Abcam reference reagent ab194785, validated for immunofluorescence (IF) staining workflows on human and rat samples, and used in neuroscience and neuroendocrine research into dopaminergic and noradrenergic pathways.

Phosphorylation of TH at Ser19 increases catalytic activity and is commonly studied in models of neuronal activity, stress response, and Parkinson disease research, complementing antibodies that recognize the alternative Ser40 PKA site. Because the antibody is unconjugated, it can be paired with fluorophore-labeled secondary reagents chosen by the researcher for imaging fixed cells or tissue sections. Its polyclonal format offers broader epitope coverage than monoclonal alternatives, helpful when mapping phosphorylation dynamics across different experimental conditions.

Storage at low temperature in working aliquots is recommended to preserve phospho-specific recognition, with limited freeze-thaw cycles advised to maintain antibody integrity for IF detection of phosphorylated TH. This research-use-only reagent is intended for in vitro immunofluorescence applications.