Anti-TGM5 Antibody

The polyclonal reagent targets transglutaminase 5 (TGM5), a calcium-dependent enzyme that catalyzes cross-linking of structural proteins during terminal keratinocyte differentiation in the upper epidermis. Researchers studying epidermal barrier formation, cornified envelope assembly, and the molecular basis of acral peeling skin syndrome — a genodermatosis linked to loss-of-function TGM5 mutations that disrupts stratum corneum integrity — will find this reagent useful for probing disease mechanisms and normal skin biology.

Supplied as a 100 µl vial at 1 mg/ml in PBS with 0.1% sodium azide and 50% glycerol, this unconjugated product from Antibodies.com is validated for immunoblotting, immunohistochemistry, and immunofluorescence workflows on human, mouse, and rat samples. For best stability, store frozen at -20 °C, protected from light, and aliquot upon receipt to limit freeze-thaw cycles of the polyclonal antibody solution.

The polyclonal format provides broader epitope coverage than a monoclonal alternative, which is helpful when mapping TGM5 expression in differentiating keratinocytes, skin biopsy sections, or cultured epithelial model systems.