Anti-TGFBR2 Antibody

This polyclonal antibody from Antibodies.com targets Transforming Growth Factor Beta Receptor 2 (TGFBR2), a transmembrane serine/threonine kinase that mediates TGF-β signaling and plays a central role in fibrosis, epithelial-mesenchymal transition, and tumor progression research.

Raised in rabbit and supplied as an unconjugated reagent in a 100 µl volume, the antibody recognizes TGFBR2 across human, mouse, and rat samples, supporting translational studies that span multiple model systems. Validated applications include Western blot for receptor expression and phosphorylation studies, as well as immunofluorescence for subcellular localization.

TGFBR2 sits at the membrane-proximal step of the canonical TGF-β pathway, recruiting and phosphorylating TGFBR1 upon ligand binding, which then activates SMAD2/3 to drive downstream transcriptional programs. Researchers investigating extracellular matrix remodeling, cardiac and pulmonary fibrosis, cancer cell invasion, or developmental biology routinely use this receptor as a marker or functional readout.

As a research-use-only reagent, this polyclonal offers broader epitope coverage than monoclonal alternatives, which can help when detecting processed or post-translationally modified forms of the receptor.