Anti-TGFB1 Antibody

Raised in rabbits against transforming growth factor beta 1 (TGFB1), this unconjugated polyclonal reagent from Antibodies.com is supplied as a 100 µl vial and validated for Western blot (WB) and immunohistochemistry (IHC) workflows. TGFB1 is a ~25 kDa homodimeric cytokine secreted as a latent precursor that requires proteolytic cleavage for activation before engaging the TGFBR2/TGFBR1 receptor complex and triggering SMAD2/3 phosphorylation. Accurate detection matters in studies of fibrosis, immune tolerance, wound healing, and the tumor microenvironment, where TGFB1 levels and downstream signaling activity are routinely interrogated. The antibody recognizes both human and mouse TGFB1, simplifying cross-species experimental design without the need to maintain parallel reagent inventories. Because it is unconjugated, the reagent can be paired with HRP, biotin, or fluorescently labeled secondary antibodies of the user's choice, giving flexibility in detection chemistry. Aliquot on arrival and refrigerate for short-term use; for longer storage keep frozen and minimize freeze-thaw cycles to preserve binding activity. This product is intended for research use only and is not cleared for diagnostic or therapeutic applications.