Anti-TFRC Antibody

This polyclonal antibody from Antibodies.com targets the transferrin receptor (TFRC), a type II transmembrane glycoprotein that mediates cellular iron uptake through binding and internalization of transferrin-bound iron. Raised in rabbit and supplied as an unconjugated reagent in a 100 µl vial, it is validated for western blot and immunohistochemistry on human samples. TFRC is widely studied as a marker of proliferating cells and erythroid precursors, and is frequently used in cancer research to characterize rapidly dividing tumor populations, in hematology to investigate disorders of iron metabolism, and in neuroscience to assess blood-brain barrier integrity under disease or injury conditions. Because the receptor drives receptor-mediated endocytosis of iron-loaded transferrin, this reagent supports work on iron homeostasis, ferroptosis, and the trafficking dynamics of cargo entering the endosomal-lysosomal pathway. The polyclonal format offers recognition of multiple epitopes on the receptor, which can be advantageous when detecting low-abundance targets or when working with samples that carry point mutations or splice variation in the extracellular domain.