Anti-TFPI Antibody

The Tissue Factor Pathway Inhibitor (TFPI) target sits at a regulatory checkpoint of the extrinsic coagulation cascade, where it restrains Factor Xa and the Factor VIIa-tissue factor complex. Antibodies.com supplies a rabbit polyclonal antibody raised against TFPI that detects the endogenous protein across human, mouse, and rat systems, supporting work that links murine models to human vascular biology.

Provided as a 100 µl volume at 1 mg/ml in PBS with 0.1% sodium azide and 50% glycerol, the unconjugated antibody can be paired with HRP, biotin, or fluorophore chemistries chosen by the end user. The 50% glycerol buffer keeps the solution fluid at -20 °C, the recommended storage temperature, and aliquoting upon receipt limits freeze-thaw exposure that can degrade antibody activity over time.

Validated applications cover western blot for expression-level confirmation in tissue and cell lysates, immunohistochemistry for spatial distribution in fixed sections, and immunofluorescence for subcellular localization studies. Cross-reactivity with three commonly used model organisms enables comparative studies of TFPI regulation in disease models of thrombosis, atherosclerosis, and endothelial dysfunction.