Anti-TFIIH (N-term) Antibody

Antibodies.com offers this mouse monoclonal antibody targeting the N-terminal region of Transcription Factor II H (TFIIH), a multi-subunit complex essential for RNA polymerase II transcription initiation and nucleotide excision repair (NER). The unconjugated IgG1 clone is validated for Western blot (WB) and immunocytochemistry (ICC) workflows, and cross-reacts with human, mouse, canine, and rat samples, enabling cross-species studies of transcription-coupled DNA repair mechanisms. Each vial contains 100 µl of ready-to-use reagent, supplied as an unconjugated primary antibody that can be paired with fluorophore- or enzyme-conjugated secondary reagents. Researchers studying xeroderma pigmentosum, Cockayne syndrome, or trichothiodystrophy pathways benefit from the antibody's specificity for the N-terminal epitope, which permits detection of full-length TFIIH subunits including the XPB and XPD helicases involved in damage recognition and strand unwinding. Compatible with standard immunostaining protocols, this reagent supports investigations into TFIIH's dual roles in basal transcription and DNA damage response.