Anti-TERF1 Antibody

This unconjugated rabbit polyclonal antibody targets TERF1 (Telomeric Repeat Binding Factor 1), a core component of the shelterin complex that binds double-stranded telomeric DNA repeats and regulates telomere length in human cells. The reagent is supplied as 100 µl of polyclonal serum, unconjugated for flexibility in detection chemistry across Western blot and immunohistochemistry workflows.

TERF1 localizes to chromosome ends, where it protects telomeric termini from being recognized as DNA damage and controls telomerase access to telomere termini. Altered expression is studied in the context of telomere maintenance, aging, genome stability, and cancer cell immortalization. Because TERF1 expression patterns differ across normal and tumor tissue, validated antibodies such as this one are used to probe these differences in cell and tissue samples.

Applications supported for this reagent include Western blot for protein-level detection and immunohistochemistry for localization studies in human samples. The host species is rabbit, clonality is polyclonal, and reactivity is specific to human TERF1. The unconjugated format allows researchers to pair the antibody with the secondary reagent or detection label of choice for their Western blot or IHC protocol. Provided by Antibodies.com, this primary antibody supports laboratory research into shelterin biology, replication stress, and the mechanisms that maintain chromosome integrity at chromosome ends.