Anti-Tensin-1 (phospho-Y483) Antibody

This polyclonal antibody from Antibodies.com targets Tensin-1 phosphorylated at tyrosine 483 (pY483), a modification associated with focal adhesion remodeling and integrin-mediated signaling. Raised in rabbit and supplied as an unconjugated reagent at 1 mg/ml in phosphate buffered saline (pH 7.2) with 0.05% sodium azide, it is validated for immunohistochemistry (IHC) on human and mouse tissue specimens. Tensin-1 acts as a scaffold at integrin-based adhesion complexes, bridging the actin cytoskeleton to the extracellular matrix and participating in cascades that govern cell migration, adhesion turnover, and cytoskeletal organization. Detection of the pY483 phospho-epitope in fixed sections supports research into cancer cell invasion, fibrotic remodeling, and integrin pathway activation in disease models. The product is provided as a 100 µl vial, sufficient for multiple staining runs, and the unconjugated format offers flexibility to pair it with a user-preferred secondary detection system, whether HRP- or fluorophore-labeled, matched to the specific IHC protocol in use.