Anti-TDP1 Antibody

TDP1 (tyrosyl-DNA phosphodiesterase 1) is the DNA repair enzyme that hydrolyzes the phosphodiester bond linking stalled topoisomerase I to DNA, and this rabbit polyclonal IgG reagent from Antibodies.com is raised against the human protein for immunofluorescence detection. Supplied as an unconjugated preparation in a 50 µl vial, the antibody localizes nuclear TDP1 expression in cells and tissue sections, supporting studies of camptothecin sensitivity and repair of topoisomerase I-induced DNA lesions. The polyclonal host response targets multiple epitopes across the human TDP1 protein, improving signal robustness in IF staining protocols that pair a fluorophore-conjugated secondary antibody. Aliquot the reagent into single-use fractions and store at -20°C to limit freeze-thaw cycles, protecting from light once a fluorescent secondary is applied. Researchers studying DNA damage response, topoisomerase I inhibitor pharmacology, and genome stability pathways in human cell lines rely on this Antibodies.com primary antibody to visualize endogenous TDP1 distribution by fluorescence microscopy.