Anti-TCN2 Antibody

The TCN2 gene encodes Transcobalamin II, a plasma glycoprotein that binds vitamin B12 (cobalamin) and delivers it to peripheral tissues through receptor-mediated endocytosis. Loss-of-function variants in TCN2 cause transcobalamin II deficiency, an inherited disorder marked by megaloblastic anemia, pancytopenia, neutropenia, and impaired cellular immunity, making the protein a longstanding target in hematology and metabolic research. This unconjugated rabbit polyclonal reagent from Antibodies.com is raised against TCN2 and is validated for Western blot and immunohistochemistry on human samples, supporting studies of hepatic protein secretion, cobalamin transport kinetics, and congenital B12 utilization defects.

The antibody is supplied as 100 µl of polyclonal antiserum, free of reporter tags, allowing flexible pairing with horseradish peroxidase, alkaline phosphatase, or fluorescent secondary antibodies of the user's choosing. Host species is Rabbit, clonality is polyclonal, target is human TCN2, and the reagent is intended for research use only. Typical workflows include Western blot analysis of whole-cell or tissue lysates to detect the ~43 kDa transcobalamin II band, and immunohistochemistry on formalin-fixed paraffin-embedded sections to localize expression in liver, kidney, and other tissues involved in systemic cobalamin handling.