Anti-TCF3 Antibody

This unconjugated polyclonal antibody from Antibodies.com targets Transcription Factor 3 (TCF3), also known as E2A or E12/E47, a basic helix-loop-helix transcription factor essential for B-lymphocyte lineage commitment and immunoglobulin gene rearrangement. The reagent is produced in rabbit and validated for Western blot and immunohistochemistry applications, with demonstrated reactivity toward human, mouse, and rat samples. Supplied as 100 µL of unconjugated antiserum, this primary antibody enables detection of endogenous TCF3 protein in cell lysates and formalin-fixed tissue sections. TCF3 functions as a master regulator of lymphocyte development and forms heterodimers with other E-proteins to control transcription of B-cell-specific genes, including those encoding immunoglobulin heavy and light chains. The reagent supports studies of lymphoid development, transcriptional regulation, and hematological malignancies including acute lymphoblastic leukemia where TCF3 dysregulation is implicated.