Anti-TBX15 / 18 Antibody

The TBX15/18 polyclonal antibody from Antibodies.com is an affinity-purified reagent raised in rabbit against the conserved T-box DNA-binding region shared by TBX15 and TBX18 transcription factors. Supplied as 100 µl of unconjugated polyclonal antiserum in a single-use vial, this Primary Antibody is validated for Western Blot, Immunohistochemistry, and Immunofluorescence workflows, with confirmed reactivity against human and mouse samples.

TBX15 (T-box 15) and TBX18 (T-box 18) are members of the T-box family of transcription factors that play key roles in embryonic development, including skeletal and cartilage formation, limb patterning, and cranial neural crest cell differentiation. Mutations in TBX15 have been linked to Cousin syndrome, a rare skeletal dysplasia, making reagents that recognise the conserved T-box domain valuable tools for developmental biology and disease research. Because the immunogen targets the shared T-box region, this antibody detects both TBX15 and TBX18 isoforms in experimental samples.

The unconjugated format provides flexibility in selecting secondary detection reagents and labelling strategies suited to each experimental system. The polyclonal nature of the reagent provides broad epitope coverage within the conserved target region, supporting consistent detection across Western Blot, IHC, and IF applications.