Anti-TBLR1 Antibody

Produced by Antibodies.com, this mouse monoclonal IgG1 reagent targets the TBL1-related protein 1, also called TBL1XR1, a scaffold component of the NCoR/SMRT transcriptional corepressor complex that mediates histone ubiquitination and modulates Wnt/β-catenin signaling output. The unconjugated antibody recognizes an epitope conserved across human, mouse, rat, and canine orthologs, making it broadly applicable for comparative work in vertebrate model systems.

Researchers deploy the reagent in western blot detection of endogenous TBLR1 in whole-cell and nuclear lysates, immunocytochemistry on cultured cells to map subcellular distribution, and immunohistochemistry on paraffin-embedded or frozen tissue sections. Published use cases include mechanistic studies of Wnt-driven transcriptional activation, characterization of TBL1XR1 loss-of-function mutations linked to autism spectrum disorder and intellectual disability, and oncology screens examining aberrant repressor-complex recruitment in B-cell lymphomas and colorectal carcinomas.

Supplied as 100 µl of liquid antibody, the product gives investigators flexibility to pair the primary with user-selected HRP, fluorophore, or biotin conjugates tailored to the experimental readout. Aliquot on receipt and store refrigerated to preserve activity; avoid repeated freeze-thaw cycles of working stocks.