Anti-TBL1X Antibody

TBL1X (Transducin Beta-Like Protein 1, X-linked) is a WD40-repeat-containing transcriptional corepressor that operates as part of the NCoR/SMRT repressor complex, recruiting histone deacetylases to chromatin and modulating nuclear-receptor-driven gene expression. This unconjugated, rabbit-derived polyclonal reagent from Antibodies.com is raised against the human TBL1X target and is supplied as 100 µl of working solution intended for western blot and immunohistochemistry workflows.

Validated applications include western blot (WB) for protein-level detection across cell and tissue lysates, and immunohistochemistry (IHC) for localization studies in fixed tissue sections. Reactivity is established for human samples, making the reagent suited for projects focused on transcriptional regulation, chromatin remodeling pathways, and X-linked gene function. The polyclonal format provides multi-epitope recognition of TBL1X, which can support a stronger and more resilient signal in research applications compared with single-clone alternatives.

TBL1X carries notable research significance in studies of X-linked sensorineural hearing loss, where loss-of-function variants have been implicated in auditory dysfunction, and in broader investigations of nuclear-receptor signaling and oncogenic transcriptional programs. Researchers studying Wnt-pathway-driven transcriptional control, ocular development, and chromatin-modifying cofactor biology may find this primary antibody a useful tool for probing TBL1X protein abundance and tissue distribution in their experimental systems.