Anti-TBL1 (4H2) Antibody

This mouse monoclonal antibody, clone 4H2, targets TBL1 (Transducin beta-like protein 1), a transcriptional co-regulator that operates within the NCoR/SMRT corepressor complex and contributes to Wnt/β-catenin signaling. Distributed by Antibodies.com, the reagent is validated for Western blot and immunocytochemistry on human-derived samples and is supplied as 100 µl of purified immunoglobulin.

The antibody is provided in a stabilizing buffer of 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl, 0.2% sodium azide, and 50% glycerol. Its unconjugated format gives researchers flexibility to apply it directly or to conjugate it with a label of their choice, while monoclonal production ensures reproducible epitope recognition across experiments.

TBL1 helps exchange corepressor complexes for coactivator complexes during nuclear-receptor-mediated transcription, in part by recruiting the 19S proteasome to chromatin-bound complexes. Investigators working on hormone signaling, transcription factor biology, chromatin remodeling, and Wnt pathway research can apply this reagent to detect endogenous TBL1 in cell lysates and fixed cells. For best results, store refrigerated and limit freeze-thaw cycles to preserve antibody activity.