Anti-TBK1 Antibody

This polyclonal antibody from Antibodies.com targets TBK1 (TANK-binding kinase 1), a serine/threonine kinase that serves as a central regulator of innate immune signaling, type I interferon responses, and selective autophagy. The reagent is raised in rabbit and supplied as an unconjugated preparation in a 100 µl vial, allowing direct incorporation into standard immunodetection workflows without prior secondary conjugation.

Validated for western blot (WB) and immunohistochemistry (IHC), the antibody detects endogenous TBK1 in samples derived from human, mouse, and rat origins, supporting cross-species work in commonly used cell line panels, primary tissues, and archived clinical specimens. Researchers investigating NF-κB and IRF3 pathway activation, STING-dependent antiviral signaling, mitophagy, or TBK1 involvement in oncogenic signaling and neurodegenerative inflammation can use this reagent to probe both baseline kinase expression and stimulus-dependent phosphorylation events.

The polyclonal format provides recognition of multiple epitopes across the target, producing robust signal in denatured lysates for WB as well as in formalin-fixed, paraffin-embedded sections for IHC. Refrigerate at 4 °C in the supplied vial to preserve antibody activity for routine bench use; aliquoting is recommended to limit repeated freeze-thaw cycles and maintain reproducible titer across experiments.