Anti-TBG Antibody

Thyroxine-binding globulin (TBG), the principal hepatic glycoprotein that carries circulating thyroxine (T4) and triiodothyronine (T3) through the bloodstream, is the target of this Rabbit polyclonal reagent from Antibodies.com. Supplied unconjugated in a 100 µl vial, it is validated for Western blot and immunofluorescence workflows applied to human specimens.

Because TBG concentrations strongly influence total thyroid hormone measurements without altering the free hormone fraction, antibodies raised against TBG are widely used to investigate inherited and acquired disorders of thyroid hormone transport. Common research applications include probing hepatic regulation of TBG expression, characterizing sex-steroid and pregnancy-driven shifts in circulating TBG levels, and localizing TBG within tissue sections by immunostaining.

As a polyclonal reagent, the antibody recognizes multiple epitopes across the TBG molecule, supporting consistent signal across diverse lysate and imaging conditions. The unconjugated format gives users flexibility to pair the primary antibody with their preferred secondary antibody — HRP, biotin, or fluorophore conjugates — depending on the assay. Aliquoting upon first use and refrigerated storage between experiments preserves antibody activity across repeated freeze-thaw cycles.