Anti-TBC1D15 Antibody

Raised in rabbit against the TBC1D15 protein, this polyclonal IgG reagent from Antibodies.com is supplied as an unconjugated preparation in a 100 µl volume for western blot detection. TBC1D15 is a Rab-GTPase-activating protein (GAP) that carries a conserved Tre-2/Bub2/Cdc16 (TBC) domain and accelerates GTP hydrolysis on Rab family members, notably Rab7 and Rab36, thereby linking Rab signaling to late endosomal and lysosomal trafficking events.

The antibody is widely applied in studies of mitophagy and selective autophagy, where TBC1D15 partners with mitochondrial fission 1 (Fis1) and LC3/GABARAP-family proteins on the outer mitochondrial membrane to drive autophagosome biogenesis and clearance of damaged mitochondria. Researchers investigating the Rab regulatory axis, mitochondrial quality control, and endolysosomal dynamics in human, mouse, and rat samples routinely use this reagent in cell lysate and tissue homogenate workflows.

Each vial delivers 100 µl of unconjugated rabbit IgG, validated for western blot across human, mouse, and rat specimens. For best results, store refrigerated, protect from light, and prepare working aliquots to limit freeze-thaw cycles of the stock over its shelf life.